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buy 3-meo pcp online 3-Methoxyphencyclidine (3-MeO–PCP) is a new psychoactive substance derived from phencyclidine. Although it can lead to severe intoxications, the main manifestations and optimal management have not been well characterized. Here, we report 2 cases of 3-MeO–PCP intoxication in the same patient, and summarize the manifestations of this intoxication reported in literature. PATIENT CONCERNS: A 17-year-old male purchased a bag of 3-MeO–PCP on the Internet but took an oral dose (200 mg) that corresponds to the less active isomer 4-MeO-PCP. He developed high blood pressure (158/131 mm Hg), tachycardia (100 bpm), and neurological manifestations (confusion, hypertonia, nystagmus, and then agitation). A maculopapular rash appeared, although this may have been related to the administration of midazolam. Hyperlactatemia (2.6 mmol/L) was the main laboratory finding. Seven days later, he returned to the emergency department after sniffing 50 mg of 3-MeO–PCP. High blood pressure, tachycardia, and neurological manifestations (psychomotor impairment and dysarthria) were present but less severe than after the first intoxication. DIAGNOSIS: In the first intoxication, the blood and urine 3-MeO–PCP concentrations were, respectively, 71.1 ng/mL and 706.9 ng/mL. Conventional toxicity tests were all negative. In the second intoxication, biological samples were not available. INTERVENTIONS: In the first intoxication, treatment consisted of intravenous hydration and midazolam. The patient was transferred to an intensive care unit for monitoring. After the second intoxication, he was monitored for 12 hours. OUTCOMES: The patient’s condition improved quickly in both cases. LESSONS: These cases provide additional information on the manifestations of 3-MeO–PCP intoxication. These manifestations are mainly cardiovascular (high blood pressure, tachycardia) and neurological. The fact that second (50 mg) intoxication was less severe than the first (200 mg) is suggestive of a dose-effect relationship for 3-MeO–PCP. The first case also emphasizes the risk of dosing errors caused by the similarity between the names ‘3-MeO–PCP‘ and ‘4-MeO-PCP.’
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3-MeO-PCP, or 3-methoxy PCP, is a dissociative substance of the arylcyclohexylamine chemical class that produces long lasting dissociative effects. It is structurally related to ketamine, but with an additional methoxy group attached to its chemical structure. Because of its structural similarities to ketamine, it has been sold online as K at a cheaper price than pharmaceutical products. There have been many anecdotal reports of other non-ketamine substances being missold as ketamine. These reports suggest that consumers should be extremely cautious when purchasing any product online and should ensure that they are 100% certain of what they are ordering.
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3-MeO-PCP belongs to a family of drugs called dissociatives. The effects of 3-MeO-PCP are thought to come from its activity at NMDA receptors, which are involved in regulation of consciousness and sensory perception. While it has no stimulant effect on dopamine levels, its action at these receptors is believed to cause 3-MeO-PCP’s effects of amnesia and analgesia. Very little data exists about possible interaction between PCP and amphetamine, but if their respective pharmacological profiles are any indication, they likely act on different neurotransmitter systems (dopamine vs. glutamate) and may be quite safe when taken together.
3-meo pcp or 3-methoxyeticyclidine is a synthetic dissociative of the arylcyclohexylamine chemical class. It produces dissociative, anesthetic, stimulating and hallucinogenic effects when administered. Closely related to methoxetamine, it is speculated to produce similar effects with higher potency and more sympathomimetic effects. 3-meo pcp was first reported in 2010 on websites where it was being sold as a designer drug.